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Glucagon-like peptide-1 (GLP-1) is a peptide hormone that is produced in the intestine and in multiple other sites that are known for their role in regulating glucose metabolism. GLP-1 is also involved in multiple other physiological processes including appetite, cardiovascular function, and inflammation (1).
Acute Inflammation is central to in-vivo responses to a wide range of challenges including viral and bacteriological infections, and to host repair processes. Chronic inflammation, on the other hand, is associated with conditions like type 2 diabetes, metabolic syndrome, obesity, cancer, arthritis, and bowel diseases like Crohn’s disease and ulcerative colitis (2). Our recent studies have revealed the anti-inflammatory properties of several peptide hormones such as hCG, oxytocin, ghrelin, and vasopressin (3–6). We focus on the anti-inflammatory properties of the incretin hormone ‘Glucagon-like Peptide-1 (GLP-1). Known for promoting glucose homeostasis and weight loss, the anti-inflammatory properties of GLP-1 suggest that it may also blunt inflammation and protect against organ damage (3–6).
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